Immunity to seasonal and pandemic influenza A viruses

SA Valkenburg; JA Rutigliano; AH Ellebedy; PC Doherty; PG Thomas; K Kedzierska

Journal article

Immunity to seasonal and pandemic influenza A viruses

SA Valkenburg, JA Rutigliano, AH Ellebedy, PC Doherty, PG Thomas, K Kedzierska

Microbes and Infection | Published : 2011

DOI: 10.1016/j.micinf.2011.01.007

Abstract

The introduction of a new influenza strain into human circulation leads to rapid global spread. This review summarizes innate and adaptive immunity to influenza viruses, with an emphasis on T-cell responses that provide cross-protection between distinct subtypes and strains. We discuss antigenic variation within T-cell immunogenic peptides and our understanding of pre-existing immunity towards the pandemic A(H1N1) 2009 strain. © 2011 Institut Pasteur.

University of Melbourne Researchers

Peter Doherty Author

Katherine Kedzierska Author

Sophie Valkenburg Author

Related Projects (2)

UNDERSTANDING AND CONTROLLING INFLUENZA

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Grants

Awarded by National Institutes of Health

Funding Acknowledgements

KK is an NHMRC RD Wright Fellow and SAV is a recipient of the Australian Postgraduate Award. POT, JAR and PCD are supported by NIH AI070251, AI077714 and NIAID contracts HHSN272200800058C and HHSN266200700005C. This work was funded by the Australian National Health and Medical Research Council (NHMRC) Urgent Call for Research on H1N1 Influenza 09 grant (AI628965) awarded to KK and and NHMRC Program Grant awarded to PCD (AI567122).